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According to the NICE Clinical Knowledge Summary (CKS) and the British National Formulary (BNF) , the standard treatment for B12 deficiency without neurological symptoms involves: Hydroxocobalamin 1 mg intramuscularly three times weekly for two weeks Followed by maintenance doses of 1 mg every three months For patients with neurological symptoms (such as paraesthesia, numbness, cognitive changes, or gait disturbances), more intensive treatment is required: Hydroxocobalamin 1 mg intramuscularly on alternate days until no further improvement occurs Followed by 1 mg every two months for maintenance Pernicious anaemia , an autoimmune condition where the body cannot produce intrinsic factor, requires lifelong treatment
It is suitable for GLP-1 analogues, amylin analogues, most neuropeptides, and the majority of water-soluble peptide compounds supplied by Peptides Lab UK
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When Dax Sheperd recently asked me about peptides in his popular Armchair Expert podcast, I gave him an overview without the details provided in this post
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