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First-in-human phase I study of JPH203, an L-type amino acid transporter 1 inhibitor, in patients with advanced solid tumors

The FDA cited concerns including potential heart-related adverse events in available safety data and the general Category 2 rationale of insufficient safety information for compounding

2 There is therefore a direct relationship between liver health and glutathione levels

The decrease in viability of all the skin cancer cell lines except for SCC-25 cells implies a possible role of this combination treatment in this type of cancers, although the SCC-25 cells intrinsic resistance should be deepened