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Patents cover coformulations with SGLT2 inhibitors, incretin combinations, and thyroid receptor agonist pairings [25, 26], reflecting the clinical reality that many patients will benefit from multi-mechanism approaches

Signaling Cascade As already elucidated in the previous section, GLP-1-RA have demonstrated significant effects on hMSC and other progenitor cells behavior, by modulating differentiation, enhancing cell survival and regulating inflammation through multiple intracellular pathways

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