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Likewise, it counteracted the already established late lidocaine-induced effects (i.e., given later after lidocaine, with a 10 min delay) [60] (i.e., the local sequestration of highly lipid-soluble anesthetics may allow for continual release to the neuronal membranes, prolonging duration [285])

In March 2026, Roche reported that the Phase 2 ZUPREME-1 trial produced mean body-weight reductions of up to 10.7% at week 42 versus 1.7% with placebo under the reported analysis

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