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ADI-R Autism Diagnostic Interview-Revised ADOS Autism Diagnostic Observation Schedule ASD Autism Spectrum Disorder CARS Childhood Autism Rating Scale CBC Complete blood count CBCL Childhood Behavior Checklist CMP Comprehensive metabolic panel CRWP Cysteine-rich whey protein GSH, Glutathione (active reduced form) GSSG, Glutathione (inactive oxidized form) MSEL Mullen Scales of Early Learning NAC N-acetylcysteine PLS-5 Pre-school Language Scale- 5th edition ROS Reactive oxygen species RRBI Restricted and repetitive behaviors and interests SAM S-adenosylmethionine SAH S-adenosylhomocysteine SCQ Social Communication Questionnaire tGSH Total glutathione (reduced + oxidized) VABS-II, Vineland Adaptive Behavior Scale 2nd edition

Chang C-H, Tsai W-C, Lin M-S, Hsu Y-H, Pang J-HS

It was showed that a GLP-1 analogue with improved half-life in a NEP 24.11 degradation assay had prolonged action in mice, therefore making this assay relevant to evaluate the potential efficacy in vivo of our compounds 40