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Another big question is whether maintenance dosing can stop the backsliding

The absence of leg cramps from official labeling does not definitively rule out a connection, as post-marketing experience sometimes reveals adverse effects not detected in pre-approval trials due to sample size limitations, duration of follow-up, or patient population differences

Atri, A., et al., evoke and evoke+: design of two large-scale, double-blind, placebo-controlled, phase 3 studies evaluating the neuroprotective effects of semaglutide in early Alzheimers disease

Al-Oqail MM, Al-Sheddi ES, Farshori NN, Al-Massarani SM, Al-Turki EA, Ahmad J, Al-Khedhairy AA, Siddiqui MA