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SUMMARY FDA-indication and practice recommendation: Semaglutide (Wegovy formulation) received accelerated FDA approval in August 2025 for treating MASH with moderate-to-advanced fibrosis (consistent with stages F2F3 fibrosis), based on phase 3 ESSENCE interim trial results where 72 weeks of 2.4 mg/week subcutaneous injection resulted in achievement of both primary histologic endpoints: (1) resolution of MASH without worsening of fibrosis (62.9% vs

B12-deficiency anemia can cause further complications, such as: difficulty walking uncontrollable muscle movements changes in smell or taste unintentional weight loss bleeding infection permanent brain or nerve damage B12 deficiency and anemia There are Diet: A person whose diet does not contain enough B12 can develop a deficiency after around 3 years, after which the body may begin to run out of stored B12

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