Poor sleep alone is associated with increased hunger, stronger sugar cravings, higher cortisol levels and reduced insulin sensitivity
Pregnancy Safety Is Unclear: The safety of GLP-1 RAs during pregnancy is not well understood
Supplements to Avoid and Drug Interaction Profiles High-dose stimulant supplements (caffeine above 200 mg, synephrine, yohimbine) can increase blood pressure and heart rate unpredictably when combined with tirzepatide's GIP receptor activation, which already affects cardiovascular signaling
Shimmura C, Suzuki K, Iwata Y, Tsuchiya KJ, Ohno K, Matsuzaki H, Iwata K, Kameno Y, Takahashi T, Wakuda T, Nakamura K, Hashimoto K, Mori N (2013) Enzymes in the glutamate-glutamine cycle in the anterior cingulate cortex in postmortem brain of subjects with autism