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To reduce the risks, especially of severe ADRs or unfavorable outcomes, stakeholders should promote the correct use and dispensing of drug with increased carefulness in patient counselling to improve healthcare outcomes [125]

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C57BL/6J congenic gut-corrected Cftr KO-Tg mice that possess a S489X truncated mutation in the murine equivalent to CFTR and have intestinal specific expression of normal human Cftr driven by the fatty acid binding promoter were originally obtained from Case Western Reserve University's CF Animal Core, as previously described [18]