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An increased risk was also supported by results of a large meta-analysis comprising a total of 36 double-blind randomized clinical trials with DPP-4 inhibitors with a total of 54,664 patients: there was a 58% increased risk of acute pancreatitis with DPP-4 inhibitors compared with other therapies (127)

doi: 10.1186/s13072-016-0081-5 127 Vailati-RiboniM.ZhouZ.JacometoC

A 2024 study from Epic Research found that people with hypothyroidism who lost more than 5 pounds while taking GLP-1 medications (including semaglutide) saw TSH (thyroid-stimulating hormone) levels decrease by an average of about 0.55 mU/L

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