Pharmaceutical agents such as Cox-2 inhibitors, thalidomide, megestrol, medroxyprogesterone acetate, melatonin, and DCA, and supplemental nutrients or antioxidants from food [35], such as -3 poly-unsaturated fatty acids, vitamin C, vitamin D, vitamin E, -hydroxy--methylbutyrate (HMB) [36] and lycopene, represent potential anti-cachexia treatments that are being explored in clinical trials
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In addition, the bioavailability of HMs may be improved by the use of chelating compounds and microorganisms, which, in turn, facilitates their accumulation in plants (Olaniran et al., 2013)