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In AD, altered GSH levels in both the brain and blood have been associated closely with disease progression and cognitive decline ( 2 Mechanisms of redox regulation in the CNS 2.1 GSH as an antioxidant in the brain The brain, being one of the most metabolically active organs in the body, requires a large share of oxygen relative to its mass

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In a 12-month randomized study of healthy older adults, MK-677 enhanced pulsatile growth hormone secretion and significantly increased fat-free mass compared with placebo