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A also stimulates the activation of NADPH oxidases (NOXs), integrin Iib-3, and ROS, promoting platelet adhesion, increasing levels of the endogenous inhibitors plasminogen activator inhibitor-1 and endothelin-1 (ET-1), and resulting in thrombosis, capillary constriction, and impaired blood flow [99, 181, 182]

Acute Lyme Disease Symptoms: Fatigue Migratory muscle and joint pain Headaches Neck pain Memory challenges Sleep issues Symptoms of Chronic Lyme Disease: Its quite common for Lyme to either go undetected or not respond to initial treatment (more on this below)

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