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Glutathione + MOTS-c Frequently investigated in: Metabolic-regulation research Mitochondrial-signaling pathways Cellular-energy investigations Recovery-focused metabolic pathways Physiological-resilience research Research commonly explores the relationship between antioxidant-support pathways and mitochondrial-related signaling mechanisms

Treated animals showed delayed onset of age-related pathologies, better preservation of organ function, maintained reproductive capacity, reduced tumor incidence, and improved healthspan

NBDHEX acts as an anticancer agent by inhibiting GSTs catalytic activity, avoiding inconvenience of the inhibitor extrusion from the cell by specific pumps and disrupting the interaction between the GSTP1-1 and key signaling effectors

Acknowledgments The authors are grateful to Yixin Wang, Wei Wang and Meiliang Pan for writing the original draft