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FIGURE 1 This chemical architecture integrates the inherent stability of the steroidal framework with the functional versatility of side chain/glycosyl substituents, endowing caudatin with the ability to interact with multiple molecular targets such as uPA (Urokinase-Type Plasminogen Activator), MMP9 (Matrix Metalloproteinase 9), and JAK2 (Janus Kinase 2) ( 2.2 Structural stability The rigid architectural framework of the caudatin steroidal scaffold, in conjunction with the chemical microenvironment of specific functional groups, serves as the foundational basis for its biological activity

A recent study also demonstrates that ceritinib inhibits InsR phosphorylation and induces tumor regression in a pediatric patient with an unclassified brain tumor [204]

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