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In the Phase 2 obesity trial, the 12 mg weekly dose produced a mean weight reduction of about 24.2% at 48 weeks ( Jastreboff et al., NEJM 2023 ) the largest figure reported for any single agent in the incretin class at the time

In a separate subgroup analysis, we also assessed how changes in weight, HbA1c, and composite outcomes were impacted by persistence with semaglutide OW treatment and dose

There is an increased risk of diabetic retinopathy for those that have diabetes and have a history of diabetic retinopathy and a rapid reduction in the A1c

The robust weight loss outcomes observed in clinical trials were achieved in diverse populations with varying dietary habits, including those who likely consumed caffeine regularly