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Additionally, hemin (a porphyria therapeutic agent) has been shown to upregulate GPX4 via the HO-1/NRF2 signaling pathway, thereby inhibiting oxidative stress and ferroptosis, which alleviates CIN (265)

Passiflora subpeltata Ortega According to a study from Brazil, luteolin and quercetin 3--d-glucoside were newly detected as compounds in Passiflora subpeltata Ortega leaves, and an acetone extract of this plant was found to elevate the serum white blood cell, red blood cell, and hemoglobin counts, and retain the serum biochemical and antioxidant levels to normal range, providing protection against ALI (Shanmugam et al., 2016)

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