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Small human studies have shown that allulose consumption can modestly increase postprandial GLP-1 levels compared to control conditions

Rather, he thinks their ability to reduce appetite occurs by stimulation of parts of the brain that sit outside the bloodbrain barrier the selective semi-permeable membrane that keeps most large molecules out

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The average weight loss with Wegovy injection was 14.9% (34.6 lb / 15.7 kg) from a starting weight of 232 lb (105 kg) after 68 weeks in the STEP 1 clinical trial (NCT03548935), compared with 2.4% (5.5 lb / 2.5 kg) with placebo