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Proteomic analysis focused on 19 CYP450 enzymes, 36 non-CYP Phase I enzymes, 36 Phase II enzymes, and 95 drug transporters (16 ATP-binding cassette [ABC] transporters and 79 solute carrier [SLC] transporters)

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When a mutation occurs, the conservative properties of the subcellular organelles (such as structure and composition) are not easily altered [81]