The basal-like subtype, commonly referred to as triple negative, lacks ER, PR, and HER2 expression, accounts for approximately 15% of breast cancers, and is associated with poor prognosis (137139) HER2-enriched tumours display high HER2 expression, increased proliferation, and are typically ER- and PR-negative ( Figure 5 ) (135, 140, 141)
Funding This work was supported by Beijing Municipal Administration of Hospitals Incubating Program (PX2023026) and 2024 Evidence-Based Medical Quality Management Research Project of the National Institute of Hospital Administration, National Health Commission of the People's Republic of China (YLZLXZ24G091)
Wow, very informative article
It has an extended half-life (1 week) due to its structural modifications, allowing for once-weekly subcutaneous administration