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When comparing semaglutide and tirzepatide, the experimental system should be reported in full, including receptor construct, receptor species, host-cell background, receptor-expression level where available, assay platform, incubation time, concentration range, protein-binding conditions, normalization method, reference ligand, and statistical model

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LeiterLA,BainSC,BhattDLetal.The effect of glucagon-like peptide-1 receptor agonists liraglutide and semaglutide on cardiovascular and renal outcomes across baseline blood pressure categories: Analysis of the LEADER and SUSTAIN 6 trials.Diabetes Obes Metab.2020;22(9):1690-5

MC4R represents one of the most widely studied individual applications of MT-2 in laboratory research