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Upon its efflux from cells, oxidised glutathione is exposed to the sequential action of enzymes located on the external face of the cell membrane: -glutamyl transpeptidase (GGT) generates glutamate 94 and the cysteinylglycine dipeptide, which is degraded by dipeptidases such as aminopeptidase N (APN), thereby releasing cysteine and glycine

Positron emission tomography (PET) studies provide direct in vivo evidence supporting the aforementioned processes

Proceedings of the National Academy of Sciences, 120 (29) e2305871120, e2305871120

Furthermore, research has shown that sleep deprivation may decrease glutathione levels