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It is noteworthy that the ER is considered an initiating site of lipid peroxidation during ferroptosis, as the earliest signs of ferroptosis are observed on internal membranes, especially the ER, before lipid peroxidation is detected at the plasma membrane 33

It contributes to protein synthesis and the maintenance of other cellular components

23 NADPH is also needed for dihydrofolate reductase (DHFR) enzyme to catalyze the reduction of dihydrofolate to tetrahydrofolate (THF) in folate metabolism, which is required for de novo biosynthesis of thymidylate, purines, methionine, and some amino acids

Enzim ini mempengaruhi tingkat melanin pada kulit, sehingga menimbulkan peningkatan pada warna kulit yang cerah dan merata