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Importantly, these are associated with higher doses and aggressive dose escalation, not the microdosing range

In Phase II detoxification, the liver attaches a glutathione molecule to a toxin, making it water-soluble so it can be safely flushed out of the system

These variables, which were selected because they are likely to affect treatment outcomes, encompassed both demographic factors (region, sex, age at index date) and clinical history (baseline HbA1c, baseline weight, CVD in the past 365 day [coronary heart disease, cerebrovascular disease, peripheral vascular disease or heart failure], CharlsonDeyo risk index score), as well as index year, insurance type and previous receipt of oral antidiabetic medications