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Description

Steady state is reached in 4 to 5 weeks of weekly dosing at each dose level -- which is why the standard titration holds each dose for 4 weeks before escalating

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Many individuals notice sagging or sunken skin, particularly around the face, as they lose fat

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Some aspects of this, in relation to cell proliferation can already be ascertained in standard in vivo toxicity testing for pesticides and pharmaceuticals (e.g., in OECD TG 407/408) (258)

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doi: 10.3390/ijms222413384

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