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64,65,66 As a transcriptional factor, SOX10 activates various targets like MITF, long non-coding RNA (lncRNA) SAMMSON, forkhead box D3 (FOXD3), and RAB7 to regulate cell proliferation, mitochondrial function, and endolysosomal pathway, therefore affecting various biological activities in melanoma 67,68,69,70 (Fig

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18.,19 Zinc Zinc is the second most abundant trace mineral, is required by more than 300 enzymes, and binds to over 2500 proteins approximately 10 percent of all human proteins

Thirdly, non-linear behavior of capacity-limited elimination and the principles of drug accumulation upon repeated dosing are introduced