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demonstrated that PF activates the JNK/Nrf2/HO-1 signaling pathway and interacts with the PDLIM1/RhoA/ROCK1 pathway to protect SOD (PIG1, PIG3V) from oxidative damage

So while creatine won't show up on a list of "fat-burning supplements," it's a powerful tool for improving body composition, losing fat while maintaining or even gaining muscle

The identification of several genes involved in these processes sets the stage for disease development and maintenance

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