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Once translocated into systemic circulation, LPS activates toll-like receptor 4 (TLR4), triggering NF-B-mediated release of proinflammatory cytokines ( e.g ., TNF-, IL-6) and further aggravating insulin resistance and ovarian inflammation (69)

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The means the standard deviations (SD) of the ages were 61.7 10.8 years for the RA cases and 61.8 10.5 years for the controls

7f), whereas R 2 relaxation rates in the TAD1 and TAD2 regions increased substantially (Supplementary Fig