surmount trial tirzepatide SURMOUNT-3 study design This is a phase 3, multicenter, randomized, ESC 2025: post-hoc SURMOUNT-5 data

Semaglutide Safety and Efficacy Alongside HRT Clinical evidence shows no direct drug interactions between semaglutide and standard HRT regimens (estrogen, progesterone, or combination patches and pills)

"There are some [people] that, despite doing all of this, might have difficulty losing weight, and for those, I recommend talking to a provider to review the variety of medications and interventions that might help."

and Long, Y

SURMOUNT-5 primary publication) Zepbound (tirzepatide) showed superior weight loss over Wegovy (semaglutide) in complete SURMOUNT-5 results (Eli Lilly press release, 2025) Zepbound full prescribing information (Eli Lilly, FDA-approved label