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While not without challenges, the cardio-renal benefits of these agents offer meaningful improvements for patients with few other options

As a synthetic analog of its endogenous exendin-4, compared with exendin-4, LIXI deleted one proline and added six lysine residues, which increased its binding affinity with the GLP-1R by four times and increased its circulating half-life ( A prospective clinical study from Spain found that besides controlling blood glucose (fasting blood glucose and glycosylated hemoglobin), LIXI can also improve blood lipids, especially total cholesterol and triglyceride ( In clinical studies, LIXI has shown the benefits of weight loss, which is well tolerated by patients and can meet the needs of overweight patients for weight control

Trulicity (dulaglutide) weekly injection dosing schedule Trulicity is started at 0.75 mg per week and titrated as follows: Weeks 1-4 (starting dose): 0.75 mg once a week Weeks 5-8 : 1.5 mg once weekly Weeks 9-12 : 3 mg once weekly if the lower dose is ineffective

Diabetes Obes Metab (2017) 19(3):4218