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[56] However, fair credit for the first description of Graves' disease goes to the 12th-century Persian physician Sayyid Ismail al-Jurjani, [57] who noted the association of goiter and exophthalmos in his Thesaurus of the Shah of Khwarazm , the major medical dictionary of its time

Melatonin depicts pleiotropic actions as a circadian synchronizer, sleep facilitator, mitochondrial protector, immunomodulator, and neuroprotective agent