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10.1038/s41598-018-33385-z Summary Keywords nitazoxanide, methotrexate, hepatotoxicity, endoplasmic reticulum stress, rat Citation Mahmoud NM, Elshazly SM, El-shaarawy F, Zaitone SA, Aldahish AA, Ahmed GA, Fawzy MS, Aloyouni SY, Abed SY, Saeedi T and El-Sayed SS (2024) Nitazoxanide mitigates methotrexate hepatotoxicity in rats: role in inhibiting apoptosis and regulating endoplasmic reticulum stress

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Causes can include: Central nervous system issues affecting the brain or spinal cord Abnormalities of the chest wall or diaphragm Metabolic imbalances, such as abnormal calcium levels Seek evaluation promptly if hiccups last beyond two days, or if they cause: Weight loss Severe sleep disruption Dehydration Conditions That Can Cause Hiccups A wide range of medical conditions can increase the risk of hiccup