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The Se-Se bonds in the nanosheets can interact with GSH, which synergizes with the valence states transition of manganese ions, resulting in enhanced reduction of GSH levels
Kurylenko O, Rozenfelde L, Khroustalyova G, Vasylyshyn R, Ruchala J, Chang C-R, Daugelavicius R, Sibirny A, Rapoport A (2019) Anhydrobiosis in yeasts: glutathione synthesis by yeast Ogataea (Hansenula) polymorpha cells after their dehydration-rehydration
The mechanism of hyperpigmentation in seborrhoeic keratosis involves the high expression of endothelin-converting enzyme-1alpha and TNF-alpha, which stimulate secretion of endothelin 1