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The assessment of TEAE severity was based on the Amgen standard grading scale as follows: mild (aware of symptom, but easily tolerated), moderate (discomfort enough to cause interference with usual activity) and severe (incapacitating with inability to do work or do usual activity)

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Eur J Nutr (2011) 50(4):21933.10.1007/s00394-011-0197-0 9 BrestoffJRArtisD