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Sermorelins metabolic effect data is significantly thinner, with most published studies focusing on IGF-1 and modest body composition shifts rather than visceral fat-driven metabolic improvement

Another consideration is body composition changes

10.1007/s00125-022-05854-8 103 LombardiA.CantiniG.PiscitelliE.GelminiS.FrancalanciM.MelloT.et al (2008)

Zhou emphasized that the findings are preliminary because they are based on a small number of mice and require confirmation in larger animal studies and eventually in humans