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Most cases occurred only when it was administered along with metformin and insulin

Common side effects include nausea, constipation, and diarrhoea, typically most pronounced during dose escalation periods

Gastric inhibitory polypeptide as an endogenous factor promoting new bone formation after food ingestion

Who Should Not Use Contrave Contrave is not recommended for patients who: Take chronic opioid medications Have a history of seizures Have uncontrolled anxiety or panic disorders Have uncontrolled hypertension Are pregnant or planning pregnancy These safety considerations help ensure that Contrave is used only in appropriate clinical contexts