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GLP-1RAs demonstrate preventive and therapeutic potential in pancreatic cancer, hepatic cancer and CRC, require caution in MTC, and exhibit paradoxical effects in breast cancer and EC

Possible complications related to GLP-1 use under anesthesia include: Aspiration due to delayed gastric emptying Hemodynamic instability: pronounced hypotension or bradycardia Altered response to opioids and sedatives, requiring dose changes Perioperative hypoglycemia from additive glucose-lowering effects Nausea and vomiting increasing postoperative airway risk Delayed recovery of bowel function, affecting discharge timing Interference with regional anesthesia sympathetic block assessment Post-Surgery Restart Post-surgery restart of GLP-1 receptor agonists should be done with clear criteria and close coordination to avoid complications and maintain therapeutic goals

It supports healthy insulin function and helps maintain blood sugars in the normal range

Long-Term Metabolic Changes and Weight Regain Patterns Beyond appetite suppression, semaglutide produces lasting metabolic shifts through beta-cell preservation and improved insulin sensitivity that may persist partially even after discontinuation