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This memory can reportedly last 5-10 years after weight loss (yikes!), 6 which helps explain why maintaining weight loss feels like a permanent uphill battle

IGF-1 availability is tightly regulated by the so-called insulin- like growth factor binding proteins (IGFBPs), which may act by increasing IGF-1 half-life, from minutes to hours (most commonly by forming a tertiary complex with Acid-Labile Subunit and IGFBP3), however blocking its binding to the insulin-like growth factor 1 receptor (IGF- 1R) [7]

Tirzepatide and liraglutide work through a related GLP-1-driven mechanism