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According to the data derived from the SBVS, the interaction between DPDPE and GLP1R was characterized by a similar localization than danuglipron and orforglipron, within the TM bundle, and more concretely, closer to TM1-2 region (Figure 4)

10.1016/j.physbeh.2015.10.031 [DOI] [PMC free article] [PubMed] [Google Scholar] Dossat, A

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I provide details regarding the development of GLP-1 receptor agonists for anti-obesity therapy and discuss the possible mechanism behind their beneficial effects on adverse cardiovascular events