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doi: 10.1016/0014-5793(95)01272-9 87 CollierJJBurkeSJEisenhauerMELuDSappRCFrydmanCJet al

, but in this case its justified I believe

You would go up a lot

Treatment of breast and ovarian cancer cells with the duel IGF-1R/IR tyrosine kinase inhibitor (TKI) BMS-536924 caused a reciprocal upregulation of the erbB family of receptors which conferred resistance to IGF-1R inhibition [48]