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While the mechanisms underlying APAP-mediated lysosomal instability or permeabilization are not fully understood, the iron chelator desferal prevented mitochondrial depolarization and hepatocellular death after APAP exposure (Kon et al., 2010)

Li, S., Shin, H

D2R Several lines of evidences suggest that D2R signaling alleviates neuroinflammatory injury by CRYAB/STAT3 pathway, -arrestin2/NLRP3 pathway, and its regulation of macrophage phagocytic activity (94, 118)