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Primary risks include additive cardiovascular effects (increased heart rate and blood pressure), intensified gastrointestinal symptoms (nausea, vomiting, diarrhea), and potential for serious adverse events including pancreatitis and acute kidney injury requiring close monitoring

Fewer Side Effects : Tirzepatide is reported to cause fewer side effects such as nausea, vomiting, and constipation, while providing better appetite control compared to Semaglutide

Injectable semaglutide may be slightly more effective for blood sugar control than oral semaglutide, according to clinical trials

Starting above 0.25 mg is technically off-label but is commonly used in specialist obesity and endocrinology practice for patients transitioning from another GLP-1 medication