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It also forms a foundation for further interdisciplinary investigations into the dual role of this gene in tumorigenesis within melanocytesthe pigment cells in which melanoma developsand the degeneration of dopaminergic neurons, improving our understanding of why and how melanoma and Parkinson's disease are linked. Interestingly, while patients with PD have a reduced risk of developing most types of cancer, their higher-than-expected risk of melanoma has not gone unnoticed, as is the increased risk of PD in patients with melanoma

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Weeks 58: 5 mg once weekly

doi:10.1016/j.crohns.2014.02.025 24 LeeJ