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There is an inflammatory IL-6/STAT3 signaling pathway that is persistently activated in malignancy to protect tumor cells from immune cell attack (Wang et al., 2018)

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adults already on a GLP-1 and weight-loss prescriptions having doubled from 2024 to 2025, the July 1, 2026 expansion of subsidized Wegovy and Zepbound access for Medicare beneficiaries with obesity will drive a sharp uptake in branded fills among older patients, shifting volume from cash-pay channels toward manufacturer-supplied branded drugs over the next 12-24 months