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Ensure that you empty your bowels before inserting the suppository Remove the plastic wrapping from one suppository Insert it gently into the rectum (narrow end first) past the sphincter muscles with your finger (use gloves or our suppository applicator for a cleaner insertion) A suppository needs to go in at least an inch past the rim/muscle of the rectum

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10.1002/ijc.28975 34

Moreover, increased NR3C1 promoter methylation-particularly at the exon 1H region, has been observed in the PFC of individuals with alcohol use disorder, accompanied by reduced NR3C1 mRNA and protein expression 171