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[4] Richie JP Jr, Nichenametla S, Neidig W, Calcagnotto A, Haley JS, Schell TD, Muscat JE

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Sirtuins, particularly SIRT1, are involved in promoting mitochondrial biogenesis and enhancing cellular stress resistance, thereby supporting overall cellular health

Since CoA and CoA esters cannot penetrate the cell membrane, they must be converted into their respective carnitine esters by catalase and carnitine octyltransferase (COT) in peroxisomes