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Important safety information: Tirzepatide has a boxed warning for risk of thyroid C-cell tumors and is contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN2)

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But they are not the same drug, and the differences between them are now clearer than ever thanks to the landmark SURMOUNT-5 head-to-head clinical trial , the first study to compare them directly in the same patient population