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This investigation was supported by grants provided by the Geneva Cancer League, CANSEARCH, Hans Wilsdorf, Telemaque and Charles Bruneau foundations

Furthermore, we found that LTR had significant increases in serine and inosine, which are required for optimal T cell proliferation, enhanced adoptive immunotherapy, and can reverse CAR T cell exhaustion in preclinical models 15,16 , as well as lactic acid, which preclinically improves adoptive immunotherapy 17 and might be related to increased LDHA expression seen in this group (Fig

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