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Creatine supplementation may modestly increase serum creatinine levels, which reflects increased creatine metabolism rather than impaired kidney function

While many patients are suitable candidates, tirzepatide is not for everyone

The reaction should be documented in your medical records, and you should be provided with clear guidance about avoiding the medication in future and identifying suitable alternatives

Most importantly, the oligourea backbone is resistant to proteases 20 and can be interfaced with peptide -helices as it adopts an helical conformation that does not disrupt the peptide -helix propagation 16,21,24