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Next, we performed a cytokine array to gain more insight into the immune landscape in the tumor microenvironment following the combined administration of sertraline and RT (Supplementary Fig

Definition of two angiogenic pathways by distinct alpha v integrins

But the mechanistic thread (hyperglycemia and oxidative stress feeding synovial protein glycation, joint degeneration, impaired repair) is a clean hypothesis to test next

Notably, by day 3, assembloids reproducibly established key periportal architectural features, with cholangiocytes (KRT19 + nuclear green fluorescent protein (nGFP) + ) forming bile duct-like structures containing open lumina in close proximity to portal fibroblasts (nuclear red fluorescent protein (nRFP)) and both cell types embedded within the hepatocyte (HNF4A + ) parenchyma